This mechanism might be from the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the medical reaction to doxycycline needs to be monitored closely. Phenytoin, sodium valproate, valproic acid: The outcome of barbiturates over the metabolism of phenytoin appears to be variable. https://sandrav110pcp5.wikitelevisions.com/user