Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators from the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have recognized recurrent mutations in genes regulating tumor cell-microenvironment interactions, wh... https://bruceq530ipy7.bloggactivo.com/profile