In this article, we show that conolidine, a organic analgesic alkaloid used in conventional Chinese drugs, targets ACKR3, thereby giving extra evidence of the correlation among ACKR3 and soreness modulation and opening substitute therapeutic avenues for the treatment of chronic discomfort. Employed in conventional Chinese, Ayurvedic, and Thai drugs. https://josephq516gyn2.wonderkingwiki.com/user