There exists a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to decrease afferent agony transmission and deliver analgesia. Thus, medication like clonidine that focus on alpha-two receptors can affect the transmission of pain. Applies to clonidine: oral pill, oral https://shahrukhq047rdf5.wikififfi.com/user